The SAMe (S-adenosylmethionine) is a natural compound present in all tissues and human organs. It is a "brick" that is necessary for the production of many compounds produced by your body and is used in over 35 different biochemical reactions. SAMe actually donates a part of itself to form these new compounds through a process known as methylation or transmethylation. SAME is one of the few dietary supplements on the market today that combines the benefits of several nutrients into one, because the body uses the substances produced from SAMe for numerous reactions and processes in the body.
SAMe is a supplement formed in the body by an enzymatic reaction between adenosine-triphosphate (ATP) and methionine. It was discovered in 1952 in Italy and has been designed and manufactured there. SAMe works closely with folic acid and vitamin B-12 and functions as a methyl donor. This nutrient carries and donates molecules of methyl bromide necessary to facilitate the production of DNA and brain neurotransmitters. Tissue levels of SAMe are typically low in the elderly.
SAMe might be an effective treatment for depression, with fewer side effects than antidepressant drugs. But the real benefits and risks of SAMe are still unclear. In theory, may increase the risk of heart disease. People with depression or joint pain should consult a doctor before trying the SAMe. Supplementation with SAM-e increases levels of serotonin, dopamine and fosfatidi and improves the binding site of the receptors of serotonin and dopamine. Some research has shown that SAM-e provides relief from arthritis pain without the stomach irritation caused by aspirin and similar drugs.
SAMe is a dietary supplement very safe. Minor side effects include nausea and gastrointestinal irritation due to its sulfur content. These were observed only at very high doses (1200-1600m mg) and symptoms diminished with continued use. People who suffer from manic depression (bipolar disorder) should not take SAMe without prior consultation with your doctor. If you are experiencing any of the symptoms described above for a long period of time, you may be allergic to SAMe or it may not be the supplement that is right for you.
• treatment for depression
• improves the levels of serotonin and dopamine
• pain relief from arthritis
